Personally not a fan of the show. Came recommended to me by a friend... but it's just too forced and generic. It's a really generic sitcom with some geek trappings. Their idea of geekdom is pretty 'Urkel', for lack of a better word. I think a show like Chuck does a much better job with geeks, and is generally much more humorous than Big Bang
Oh, and Wil Wheaton's guest gigs prove he made the right call in leaving the full-time acting business to make software or whatever. He's terrible.