Joe Q ruined Spider-Man and Iron Man. I gave up on X-Men a long time ago (not that I'm going to blame that one on Joe), and Thor was only interesting while JMS was writing it. I spend most of my money on DC and smaller independent lines (The Walking Dead, Invincible, Irredeemable, etc.) these days. Though, I do get the Deadpool comics. Deadpool has pretty much taken over for Spider-Man as the go-to wise-cracking superhuman.
Oh, I also think the Fantastic Four comics have been on a great run for a long time now.