I'm curious about the costume. I think it'll probably be somewhat different than the Raimi/Macquire version, but not by too much. Probably a few tweaks here and there, but nothing radically different. Personally, if they are going to change it a lot, make it something like the Ben Reilly or House of M versions, which update the classic but not too by too much.
One thing I would like to see is Spider-man crack more jokes, it's very much part of the character but something that was mostly missing from the Tobey movies.