^With the exception of most of season one, no.
in the books:
-Rita is alive and became pregnant after
-La Guerta is dead (last victim of the Icetruck Killer, who isn't actually called that way)
-Dexters Brother escaped
-Dex trains Astor and Cody, due to them showing sociopatic tendencies thanks to Paul
-the Dark Passenger is actually some kind of demon
-Deb has known Dexters secret ever since Brian had kidnapped her (she was awake during their conversation) and she doesn't rat him out. She also has big boobs.