Deadline has a great interview with del Toro online conducted a week ago.
Aragorn wrote:
I'm surprised that no one has mentioned the Tom Cruise (Del Toro's choice) vs. James McAvoy (studio's choice) rumors floating around for this project. Of course they're just that -- rumors.
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Considering the project is still in budgeting and designing phases - not yet greenlit - any casting rumor is certainly just a rumor.