start with Anchorage and start early, you can't fail it and you get power armor training without unleashing the enclave, power armor that never breaks, and a suit that makes stealth boys useless, among other things, then do point lookout, it's best done early, as the inbreads get crazy HP and DR at the higher levels, Mothership Zeta is best done when you have your science and lock pick skills maxed out, the pitt is the last one I typicaly do, because of the amount of stuff you recieve from it, PM me if you want help making a perfect charater