(Ooooh, I LOVED that story, and a lot of Poe's work. A forerunner to Lovecraft, but unlike Lovecraft, not so horrifying that I can't read it without nightmares. Hm...come to think of it, maybe Poe is more of a forerunner to Hitchcock.
In my own case I had to do a lot of story work to ensure that despite appearances, the Cardassians were more similar to other species underneath than it might appear.
But a Vulcan-Andorian hybrid...that's one that in my own writing I would definitely have to nix completely, even WITH genetic engineering.