I was also intrigued by something he said in another interview-- that he felt he'd have to probably redesign the Alien itself, because of how familiar and play-out the original's become.
Frankly I have to agree with him. Now that we know what every inch of it looks like, everything it's capable of, and how it's entire damn life cycle works, there's just no mystery
to it anymore.
I wouldn't change the shape entirely, but a lot of the details definitely need to be rethought.