I doubt I'd be interested in seeing any series based on the aftermath of the most recent movie. But, If we're simply discussing the idea of an original Trek series not based on anything in particular....
hmmm.... how about Anthony Michael Hall. He did a great job with Dead Zone. Has a fairly commanding presence on screen. About the right age, I'd think.
I liked the idea of Dennis Haysbert. Loved him in the Unit. Though I could see him more as a Kirk type than a Picard.
If we're looking for somebody a bit more cerebral? Kelsey Grammer. He's well known. He's done Trek before. And, given his recent run of flops in the comedy arena he could use a dramatic role to perhaps allow people to see him as something other than Frasier.