Download the tools Colin mentioned to remove it on another PC, burn to CD or move to thumb drive.
Remove ethernet cable (paranoid step)
Boot in safe mode (press ' hold F8 just as BIOS startup screens go dark and before the windows startup banner appears), with no network support.
Install tools, eradicate malware.
Insure the malware is gone.
Turn off the bosses computer and don't screw with it any more. By not screwing with it, you help insure job security.