Perhaps Humans were the only ones who individually went as far to infiltrate Unimatrix 01?
Also, Janeway destroyed one of their TW hubs which connected to other hubs in the Galaxy and ultimately obliterated the ENTIRE TW network.
Now, granted, we don't know if any other races that came before them ever did such a thing ... but even if they did have a solution, Humans were the only ones willing to implement risky plans into actions and achieved variable results.
The destruction of the TW network would not be something minor to the Borg after all.
While I agree that the whole 'raged queen' approach was rather ... out of character, and I preferred the Borg without the queen concept to begin with, but the books can work with a premise that Janeway's actions (which were more frequent compared to Picard's) rather forced the Borg to implement a new strategy against Humans (translation: extinction).