I think a simpler solution, if you want a reset, then reset the damn universe which is too big and too convoluted and plagued by too much continuity.
The new(ish) Spectacular Spider Man cartoon is a great story, a great take on the character. It's just the old story told in today's time with a few twists and tweaks. Nothing wrong with that, nothing to complain about, easy for new fans to jump in, easy for old fans to enjoy, and Pete is young and single which fulfills Qesada's requirements. Just do the same thing with the rest of the universe and move on.