Well they are some sort of "wetware" biological beings. They could interface with technology through some means...altho on the Cylon basestars they would put their hands into a water like substance (which I could buy, we today certainly don't have a full understanding of the human genome..even if we know what it is).
The only thing I saw that didnt make any sense was when Athena jacked into the Galactica's computer. There is no interface for that...as even Cylon skinjobs were almost identical to humans. (Of course writing over technological tech tech in BSG)