I think loneliness is too essential a part of my nature to remove.
I was an Arts-and-Sciences kid born into a Church-and-Football family, so my creative and intellectual interests were always either ignored or mocked. Very lonely at home. I had some friends over the years who shared the occasional interest, but only in minor ways so my friendships were always superficial (at least from my perspective). It was worse with women, because the stereotypes are a barrier to them being interested in what I am interested in. Over the last few years, my Romantic escapades have dwindled because of a woman I knew who radically changed the way I view relationships; in the last 15 years, I've only known one woman who I considered myself compatible with, and there were some insurmountable barriers.
So I guess I'm lonely, but at peace with it; I wonder if I'd still really be me if I wasn't lonely.