How about Peter Parker: The High School Years? Follow the adventures of nerd, weakling, and social outcast Peter Parker as he... umm... studies, doesn't get invited to parties, dotes on his elderly aunt and uncle, worships Liz Allan from afar but gets nowhere with her, and does nothing even remotely heroic or dangerous. Ohh, the drama!
On the CW, Peter would still get his powers but then not want to deal with the great responsibility, and instead spend the whole time angst-filled and pining over Mary Jane while ignoring Gwen Stacy.
But someone who was bit by a radioactive spider is the only one that can stop a madman who was bit by a radioactive mantis. And a guy who was bit by a radioactive pig. And a guy who was bit by a radioactive pigeon. And a guy who was bit by a radioactive venus flytrap...