Who is this Lilith character? Wasn't Danny Huston's vamp in charge of the attack? Or was there more backstory in the graphic novel that didn't make it to the film?
Anyway, I really liked the first movie, though it sucks George won't be back, whatever her reasons are. I generally dislike recasting continuing roles in a movie series.
Lilith is essentially the Vampire 'Queen' in New Orleans if I remember correctly. It's been years since I read the comics.