Although I DID enjoy the game (and I am a sucker for post-apocolypica anyway), I found some things I didn't like about it.
The replay value is fairly low, in my opinion.
The game world feels
kinda small, even though (IIRC) it has the same actual "size" as the Cyrodiil area in Oblivion
Use of VATS was almost like using "cheat mode".
I don't think that the weapons skills really gained you much at all.