Is there? I thought the only two shortcomings the Borg had vs. the 8472 were
a) the adaptation routine didn't work on the 8472, that is, the nanoprobes didn't take, and
b) the 8472 guns were too damn powerful to be stopped by the best Borg defenses - they could blow up entire planets, after all!
Individual Drones probably weren't at a particularly great disadvantage against individual 8472 members.