The Twilight Zone and The Outer Limits are both full of stuff like this.
William Shatner, Leonard Nimoy, James Doohan, Grace Lee Whitney all appeared in The Outer Limits. There's just too many to even begin to list.
Delta Belle wrote:
Donna Douglas (The Beverly Hillbillies) in The Twilight Zone classic episode "Eye of the Beholder."
TZ had a lot of those:
Robert Redford, "Nothing in the Dark"
Dennis Hopper, "He's Alive"
William Shatner, "Nightmare at 20,000 Feet"
George Takei...dammit, can't remember the title, he plays a gardener who gets into a fight with his boss about WW II