Each have their strengths but also weaknesses. to me, my list is as follows:
1. Sisko: Fought the Dominion War and won. nuff said.
2. Janeway: Got her ship back from the Delta Quadrant facing several enemies with no support from home.
3. Kirk: Fought the Enterprise well in several encounters but made a huge tactical error in TWOK which could have doomed him fatally.
4. Picard: Fought the D and E well but lacks the killer instinct to move up the ladder.
Allright give me your list and I can expound on my reasoning if you wish.