I'm hoping the forthcoming series Virtuality
(or perhaps even Dollhouse
?) will approach this territory, but it seems almost impossible for a science fiction series to avoid these tropes all together.
Sliders wasn't a series devoted to the supernatural, at least until Tracy Tormé was jettisoned (actually before, starting with Into the Mystic
, but I will say that the series wasn't supernatural when Tormé had the most control during the pilot and season one).