Yes, you can pretty much just jump in.
The events of the DS9
books aren't really touched upon, nor are those of the New Frontier
books, the Corps of Engineers
tales, or the Klingon/Gorkon
saga. Events from the Titan
books form most of the foundation for the story, though if you read just Greater Than the Sum
and Sword of Damocles
you'll pretty much be caught up on all of the most immediately relevant backstory.
Anything else you'd need to know is recapped/explained in the books themselves.