I think this is great news. Although I did like parts of Superman Returns (I liked Routh as Clark and Kevin Spacey as Lex) the rest of the movie just didn't do it for me. Personally, I didn't mind that he had a son, I just didn't like the creepy stalker aspect of Superman. It'll be great to have a new Lois, since Bosworth looked too young and was too stiff to be Lois.
On the villain front, I wouldn't mind if Luthor was in it, but maybe in the background, setting him up to be a villain in the next movie or two movies later. If it was an origin story, then the Eradicator might be cool.